This paper outlines a five-year strategy for the CAREC WASH Centre, focusing on strengthening water, sanitation, and hygiene (WASH) systems across the CAREC region. It highlights key work pillars, including knowledge sharing, capacity building, innovation in WASH technologies, policy support, and collaboration opportunities. The paper also aligns the Centre’s goals with global and regional development strategies, such as the SDGs, and emphasizes the importance of sustainable, climate-resilient WASH systems for public health and equitable access to services.